Davide Ruggero, PhD

Professor in Residence
Urology
+1 415 514-9755
Publications: 

Androgen receptor inhibition increases MHC Class I expression and improves immune response in prostate cancer.

Cancer discovery

Chesner LN, Polesso F, Graff JN, Hawley JE, Smith AK, Lundberg A, Das R, Shenoy T, Sjöström M, Zhao F, Hu YM, Linder S, Chen WS, Hawkins RM, Shrestha R, Zhu X, Foye A, Li H, Kim LM, Bhalla M, O'loughlin T, Kuzuoglu-Ozturk D, Hua JT, Badura ML, Wilkinson S, Trostel SY, Bergman AM, Ruggero D, Drake CG, Sowalsky AG, Fong L, Cooperberg MR, Zwart W, Guan X, Ashworth A, Xia Z, Quigley DA, Gilbert LA, Feng FY, Moran AE

Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.

Nature cell biology

Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D

Functional screen for mediators of onco-mRNA translation specificity.

bioRxiv : the preprint server for biology

Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D

Abstract A078: Functional screen for mediators of onco-mRNA translation specificity in pancreatic cancer.

Cancer research

Joanna R Kovalski, Goksu Sarioglu, Vishvak Subramanyam, Grace Hernandez, Gilles Rademaker, Juan A Oses-Prieto, Macey Slota, Kwun Wah Wen, Grace E Kim, Alma L Burlingame, Hani Goodarzi, Rushika M Perera, Davide Ruggero

RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.

Molecular cell

Susanto TT, Hung V, Levine AG, Chen Y, Kerr CH, Yoo Y, Oses-Prieto JA, Fromm L, Zhang Z, Lantz TC, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M

The crosstalk between metabolism and translation.

Cell metabolism

Biffo S, Ruggero D, Santoro MM

snoRNAs in making "snoman" ribosomes.

Molecular cell

Dabrowska A, Ruggero D

Remodelling of the translatome controls diet and its impact on tumorigenesis.

Nature

Yang H, Zingaro VA, Lincoff J, Tom H, Oikawa S, Oses-Prieto JA, Edmondson Q, Seiple I, Shah H, Kajimura S, Burlingame AL, Grabe M, Ruggero D

miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress.

Molecular cancer research : MCR

Dey N, Koumenis C, Ruggero D, Fuchs SY, Diehl JA

RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.

bioRxiv : the preprint server for biology

Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame A, Ruggero D, Barna M

Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer.

Nature communications

Macaya I, Roman M, Welch C, Entrialgo-Cadierno R, Salmon M, Santos A, Feliu I, Kovalski J, Lopez I, Rodriguez-Remirez M, Palomino-Echeverria S, Lonfgren SM, Ferrero M, Calabuig S, Ludwig IA, Lara-Astiaso D, Jantus-Lewintre E, Guruceaga E, Narayanan S, Ponz-Sarvise M, Pineda-Lucena A, Lecanda F, Ruggero D, Khatri P, Santamaria E, Fernandez-Irigoyen J, Ferrer I, Paz-Ares L, Drosten M, Barbacid M, Gil-Bazo I, Vicent S

Evolutionarily divergent mTOR remodels translatome for tissue regeneration.

Nature

Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Öztürk D, Zhang Z, Ruggero D, Shokat KM, Barna M

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates.

eLife

Xu AF, Molinuevo R, Fazzari E, Tom H, Zhang Z, Menendez J, Casey KM, Ruggero D, Hinck L, Pritchard JK, Barna M

N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.

Cancer research

Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, Ruggero D, Weiss WA

Regulation of eIF4E guides a unique translational program to control erythroid maturation.

Science advances

Forester CM, Oses-Prieto JA, Phillips NJ, Miglani S, Pang X, Byeon GW, DeMarco R, Burlingame A, Barna M, Ruggero D

Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.

Nature chemistry

Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J

The promises and pitfalls of specialized ribosomes.

Molecular cell

Barna M, Karbstein K, Tollervey D, Ruggero D, Brar G, Greer EL, Dinman JD

Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate.

Molecular cell

Liedmann S, Liu X, Guy CS, Crawford JC, Rodriguez DA, Kuzuoglu-Öztürk D, Guo A, Verbist KC, Temirov J, Chen MJ, Ruggero D, Zhang H, Thomas PG, Green DR

Protein synthesis control in cancer: selectivity and therapeutic targeting.

The EMBO journal

Kovalski JR, Kuzuoglu-Ozturk D, Ruggero D

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

Cell

Xu Y, Huangyang P, Wang Y, Xue L, Devericks E, Nguyen HG, Yu X, Oses-Prieto JA, Burlingame AL, Miglani S, Goodarzi H, Ruggero D

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.

Developmental cell

Tiu GC, Kerr CH, Forester CM, Krishnarao PS, Rosenblatt HD, Raj N, Lantz TC, Zhulyn O, Bowen ME, Shokat L, Attardi LD, Ruggero D, Barna M

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome.

Cell reports

Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D

Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function.

iScience

Chiu H, Buono R, Jackson LV, Herzog LO, Mallya S, Conn CS, Ruggero D, Fruman DA

OMIC-03. TRANSLATIONAL CONTROL IN MYC AND MYCN MEDULLOBLASTOMA.

Neuro-oncology

Christin Schmidt, Albertas Navickas, Frederique Zindy, Dana Farmer, Davide Ruggero, Hani Goodarzi, Martine F Roussel, Bjoern Schwer, William Weiss

The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.

Nature metabolism

Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D

Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.

Methods in molecular biology (Clifton, N.J.)

Kovalski JR, Xu Y, Ruggero D

Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Hooshdaran N, Wei J, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ

Abstract IA17: Strategies to target the mTORC1/eIF4F axis in B-cell leukemia and lymphoma.

Molecular Cancer Research

Lee-or Herzog, Bianca J. Lee, Thanh-Trang Vo, Honyin Chiu, Sharmila Mallya, Amos Fung, Mallika Singh, James Aggen, Nidhi Tibrewal, Jacqueline A.M. Smith, David Wildes, Ze'ev Ronai, Davide Ruggero, David A. Fruman

An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.

Molecular imaging and biology

Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Nature

Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

bioRxiv : the preprint server for biology

Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ

The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications.

Annual Review of Cancer Biology

Yichen Xu, Davide Ruggero

Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.

Molecular & cellular proteomics : MCP

Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ

Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation.

Blood

Craig M Forester, Gun Woo-Byeon, Juan Oses-Prieto, Al Burlingame, Maria Barna, Davide M Ruggero

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

eLife

McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Nature cell biology

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C

Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.

Molecular cell

Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Nature cell biology

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C

Translational Control in Cancer.

Cold Spring Harbor perspectives in biology

Robichaud N, Sonenberg N, Ruggero D, Schneider RJ

Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.

ACS central science

Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.

Cell host & microbe

Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Nature medicine

Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA

A Translation Tuning HuDdle for Neurons.

Molecular cell

McMahon M, Ruggero D

Abstract 3694: Measuring oncogene signaling with transferrin-based PET: From bench to bedside.

Clinical Research (Excluding Clinical Trials)

Michael J. Evans, Charles Truillet, Davide Ruggero, Jason S. Lewis, Rahul Aggarwal, Spencer C. Behr

Development of a stress response therapy targeting aggressive prostate cancer.

Science translational medicine

Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D

Revealing nascent proteomics in signaling pathways and cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.

Cancer cell

Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Nature cell biology

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA

CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.

Neuro-oncology

Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss

New frontiers in translational control of the cancer genome.

Nature reviews. Cancer

Truitt ML, Ruggero D

Abstract A25: Sensing stress in cancer: a novel therapy targeting protein synthesis through the unfolded protein response in prostate cancer development.

Translation Control: an Adaptive Response to Oncogenic Cellular Stress

Crystal S. Conn, Hao G. Nguyen, Yae Kye, John T. Cunningham, Charles Truillet, Michael Evans, Tony L. Huynh, Peter Walters, Davide Ruggero

Abstract B11: Oncogenic KRAS regulates 4E-BP1, a repressor of cap-dependent translation, independently of growth factor activity.

Translation Control: an Adaptive Response to Oncogenic Cellular Stress

Jillian M. Silva, Rachel K. Bagni, Davide Ruggero, Frank McCormick

Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin.

Clinical cancer research : an official journal of the American Association for Cancer Research

Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

Science signaling

So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA

New frontiers in translational control of the cancer genome.

Nature reviews. Cancer

Truitt ML, Ruggero D

Automated High-Throughput Quantification Reveals Morphological Heterogeneity in Mammalian Cell Populations.

Biophysical Journal

Amy Y. Chang, Steven C. Chen, Morgan L. Truitt, Davide Ruggero, Wallace F. Marshall

A Tailor-Made Protein Synthesis Program Drives Erythroid Development and Disease.

Blood

Craig M Forester, Zhen Shi, Maria Barna, Davide Ruggero

Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.

Science signaling

Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D

Differential Requirements for eIF4E Dose in Normal Development and Cancer.

Cell

Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.

Cancer research

Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F

YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence.

Oncotarget

Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

Cancer research

Pelletier J, Graff J, Ruggero D, Sonenberg N

38 Molecular Basis of Prostate Cancer.

Long-Cheng Li, Andrew C. Hsieh, Davide Ruggero, Kirsten L. Greene, Peter R. Carroll

Early Hematopoietic Progenitors of Dkc1 Hypomorphic Mutant Mice Display Decreased Proliferation Rate and an Impaired Control of Serine/Arginine-Rich Splicing Factor 4 (Srsf4) Translation.

Blood

Antonio R Lucena-Araujo, Bárbara A Santana-Lemos, Carol H Thome, Germano A Ferreira, Davide Ruggero, Vitor Marcel Faça, Eduardo M Rego

Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.

Wiley interdisciplinary reviews. RNA

McMahon M, Contreras A, Ruggero D

Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma.

Pediatric Oncology Translational Science and Clinical Trials

Justin G. Meyerowitz, W. Clay Gustafson, Erin Nekritz, Fredrik Swartling, Kevan M. Shokat, Davide Ruggero, William A. Weiss

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer.

Cell

John T. Cunningham, Melissa V. Moreno, Alessia Lodi, Sabrina M. Ronen, Davide Ruggero

Tailor made protein synthesis for HSCs.

Cell stem cell

Barna M, Ruggero D

mTOR and Regulation of Translation.

Translation and Its Regulation in Cancer Biology and Medicine

Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero, Bruno Fonseca

Parallel measurement of dynamic changes in translation rates in single cells.

Nature methods

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T

The translational landscape of the mammalian cell cycle.

Molecular cell

Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D

Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.

Cancer Signaling Networks

Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, Davide Ruggero

Abstract A57: Plasticity of the translational landscape during the mammalian cell cycle: Implications and new insights for cancer cell proliferation.

Post-Transcriptional Regulation

Craig R. Stumpf, Melissa V. Moreno, Adam B. Olshen, Barry S. Taylor, Davide Ruggero

Assessing gene-level translational control from ribosome profiling.

Bioinformatics (Oxford, England)

Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.

Proceedings of the National Academy of Sciences of the United States of America

Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D

H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.

Cell reports

Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D

Abstract SY32-04: The translation initiation factor elF2a regulates cytoprotective autophagy in Myc-dependent lymphoma.

Molecular and Cellular Biology

Constantinos Koumenis, Lori S. Hart, Tom Cunningham, Souvik Dey, Feven Tameire, Ian Mills, Davide Ruggero, Alan J. Diehl, Serge Fuchs

Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.

The Journal of allergy and clinical immunology

Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR

Translational control in cancer etiology.

Cold Spring Harbor perspectives in biology

Ruggero D

Investigating Myc-dependent translational regulation in normal and cancer cells.

Methods in molecular biology (Clifton, N.J.)

Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D

Exaggerated translation causes synaptic and behavioural aberrations associated with autism.

Nature

Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E

Autism-related deficits via dysregulated eIF4E-dependent translational control.

Nature

Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

The Journal of clinical investigation

Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C

Translational Control in Cancer Etiology.

Cold Spring Harbor perspectives in biology

Davide Ruggero

IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Science (New York, N.Y.)

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA

Abstract 2347: Translational control and lung cancer: eIF4F activation promotes tumorigenesis in vivo.

Tumor Biology

Joel A. McCauley, Kristen Evenson, Morgan Truitt, Robert Kratzke, Vitaly Polunovsky, Davide Ruggero, Peter BItterman, Jonathan D'Cunha

The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Nature

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D

The “Fifth” RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expression at the Translational Level.

Biophysical approaches to translational control of gene expression

Mary McMahon, Cristian Bellodi, Davide Ruggero

rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.

Molecular cell

Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD

Oncogenic AKTivation of translation as a therapeutic target.

British journal of cancer

Hsieh AC, Truitt ML, Ruggero D

The cancerous translation apparatus.

Current opinion in genetics & development

Stumpf CR, Ruggero D

Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis.

Cellular and Molecular Biology

Lori S. Hart, Tom Cunningham, Tatini Datta, Huayi Liu, Albert C. Koong, Serge Fuchs, J. Alan Diehl, Davide Ruggero, Constantinos Koumenis

Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy.

Experimental and Molecular Therapeutics

Constantinos Koumenis, Haiyan Zhang, Meixia Bi, Stacey L. Lehman, Tatini Datta, Huayi Liu, Andrei Thomas-Tikhonenko, Albert Koong, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero

Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hsieh AC, Ruggero D

Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.

Cancer research

Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.

Cancer cell

Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D

Kaplan et al. reply.

Nature

Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii, David Lyden, J. Wels

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

PLoS biology

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.

Nature

Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D

130 INVITED Novel insight into the pathogenesis of dyskeratosis congenita: how defective ribosome activity can cause cancer and disease.

European Journal of Cancer Supplements

D. Ruggero, A. Yoon, G. Peng, O. Zollo, R. Adamo, N. Haynes, W. Xu, E. Rego

Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.

Science (New York, N.Y.)

Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D

Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.

Oncogene

Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.

Nature

Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D

The Akt of translational control.

Oncogene

Ruggero D, Sonenberg N

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

Nature medicine

Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP

Does the ribosome translate cancer?

Nature reviews. Cancer

Ruggero D, Pandolfi PP

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification.

Science (New York, N.Y.)

Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, Cordon-Cardo C, Pandolfi PP

Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.

Developmental cell

Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP

The puzzling multiple lives of PML and its role in the genesis of cancer.

BioEssays : news and reviews in molecular, cellular and developmental biology

Ruggero D, Wang ZG, Pandolfi PP

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.

The Journal of experimental medicine

Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP

Cis-acting signals controlling translational initiation in the thermophilic archaeon Sulfolobus solfataricus.

Molecular microbiology

Condò I, Ciammaruconi A, Benelli D, Ruggero D, Londei P

PML is essential for multiple apoptotic pathways.

Nature genetics

Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP

In vitro translation of archaeal natural mRNAs at high temperature.

FEMS Microbiology Letters

Davide Ruggero, Roberta Creti, Paola Londei

Lithium and granulocytopenia during induction treatment of adult acute lymphoblastic leukemia.

Tumori

Bandini G, Ricci P, Ruggero D, Cantore M, Visani G, Tura S

Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.

British medical journal (Clinical research ed.)

Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M

[Experience with intensive plasma exchange].

Schweizerische medizinische Wochenschrift

Gratwohl A, Cornu P, Nissen C, Ruggero D, Osterwalder B, Speck B

Serum lysozyme level in adult acute non-lymphoid leukaemia.

Haematologica

Bandini G, Ricci P, Baccarani M, Ruggero D, Tura S

Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors.

Scandinavian journal of haematology

Ruggero D, Baccarani M, Gobbi M, Tura S

Sex and prognosis in adult acute lymphoblastic leukaemia.

British medical journal

Baccarani M, Ruggero D, Gobbi M, Tura S

Ph1-positive chronic myeloid leukaemia presenting in blastic crisis: report of 12 cases.

Bollettino dell'Istituto sieroterapico milanese

Zaccaria A, Ruggero D, Guolo ML, Guarini A, Frezza R, Baccarani M, Tura S

Therapy of chronic myeloid leukemia (CML): interim report on protocols CML/73 and CML/74.

Bollettino dell'Istituto sieroterapico milanese

Baccarani M, Ruggero D, Tura S

Immunotherapy with BCG and leukemic blast cells during complete remission of acute myeloid leukemia.

Haematologica

Gobbi M, Ruggero D, Baccarani M, Zaccaria A, Tomasini I, Tura S

Nervous system involvement in adult acute myeloid leukaemia: report of five cases.

Haematologica

Ruggero D, Baccarani M, Zaccaria A, Gobbi M, Tomasini I, Tura S

Immunological study of patients with Hodgkin's disease in long-lasting not-maintained complete remission.

Bollettino dell'Istituto sieroterapico milanese

Gobbi M, Fiacchini M, Tomasini I, Ruggero D, Lauria F, Tura S

Acute promyelocytic leukemia: results of therapy and analysis of 13 cases.

Acta haematologica

Ruggero D, Baccarani M, Guarini A, Gugliotta L, Gobbi M, Ricci P, Zaccaria A, Lauria F, Tomasini I, Fiacchini M, Santucci MA, Tura S

[Progress and problems in the treatment of acute myeloid leukemia: analysis of 92 cases].

Giornale di clinica medica

Ruggero D, Baccarani M, Tomasini I, Gobbi M, Santucci MA, Guarini A, Tura S

["Cured" Hodgkin's disease in a retrospective study of 147 cases].

Giornale di clinica medica

Fiacchini M, Ruggero D, Tomasini I, Sciascia R, Emiliani E, Babini L

[Antibiotic therapy in the high risk patient (hematologic study)].

Giornale di clinica medica

Tura S, Ruggero D

A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes.

Series haematologica (1968)

Baccarani M, Zaccaria A, Santucci AM, Bagnara GP, Ricci P, Gobbi M, Ruggero D, Brunelli MA, Tura S